The folding of interphase chromatin fibres into mitotic chromosomes is acknowledged as a prerequisite for the faithful transmission of genetic and epigenetic information through cell divisions. Yet, the mechanisms by which mitotic chromosome assemble upon mitotic entry, and disassemble upon mitotic exit, remain poorly understood. Recent advances in experimental techniques coupled with fruitful collaborations with theorists have revealed key structural and mechanistic aspects.
However, a complete understanding of the structural and functional changes undergone by the genome as cells proceed through mitosis will require contributions from a broad spectrum of soft-condensed matter physics, such as polymer/polyelectrolyte physics, sol-gel phase transition, surfactant self-assembly, active matter, material elasticity, etc…
This Mitotic Chromosome Workshop aims to stimulate future experimental and theoretical research and collaborations in this area by bringing together experimentalists and theoreticians. The oral presentations will review the current knowledge and outline the various obstacles to be overcome in the future. We hope that this will fuel open and insightful discussions and open new perspectives on interdisciplinary research in this area.
The workshop will be held at ENS Lyon, January 4-5. The main speakers are:
Bill Earnshaw, Wellcome Centre for Cell Biology, Edinburgh, The UK
Mounia Lagha, CNRS, IGMM, Montpellier, France
Kazuhiro Maeshima (visio), National Institute of Genetics, Mishima, Japan
Leonid Mirny, MIT, Cambridge, USA
Kirill Polovnikov, CNRS, Institut Curie, Paris, France et Skoltech, Moscow, Russia
Jean-Marc Victor, CNRS, Sorbonne Université, Paris, France
Pascal Bernard, CNRS, ENS de Lyon, Lyon, France
Registration is free and open, but mandatory: click here to register. Those wishing to present a short oral presentation or a poster will be invited to indicate it on the site. A choice will then be made by the organizing team.
For more detailed informations:
Pascal Bernard firstname.lastname@example.org
Cédric Vaillant email@example.com
Emmanuelle Fabre firstname.lastname@example.org
Jean-Marc Victor email@example.com